Detalhe da pesquisa
1.
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.
Proc Natl Acad Sci U S A
; 120(21): e2221967120, 2023 05 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37186857
2.
Impact of PROTAC Linker Plasticity on the Solution Conformations and Dissociation of the Ternary Complex.
J Chem Inf Model
; 62(2): 340-349, 2022 01 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35018781
3.
Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery.
Angew Chem Int Ed Engl
; 61(7): e202114862, 2022 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34913249
4.
Diversity-orientated synthesis of macrocyclic heterocycles using a double SNAr approach.
Org Biomol Chem
; 19(28): 6274-6290, 2021 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34195728
5.
Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments.
J Am Chem Soc
; 142(10): 4904-4915, 2020 03 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32058716
6.
Observing an Antisense Drug Complex in Intact Human Cells by in-Cell NMR Spectroscopy.
Chembiochem
; 20(19): 2474-2478, 2019 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31206961
7.
Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes.
Nat Chem
; 16(5): 771-779, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38273027
8.
Metabolism-driven in vitro/in vivo disconnect of an oral ERÉ VHL-PROTAC.
Commun Biol
; 7(1): 563, 2024 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38740899
9.
Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.
Hum Mol Genet
; 20(18): 3545-53, 2011 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21659333
10.
Synthesis of fucosyl-N-acetylglucosamine disaccharides by transfucosylation using α-L-fucosidases from Lactobacillus casei.
Appl Environ Microbiol
; 79(12): 3847-50, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23542622
11.
Progress towards water-soluble triazole-based selective MMP-2 inhibitors.
Org Biomol Chem
; 11(38): 6623-41, 2013 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23989288
12.
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.
Bioorg Med Chem
; 21(7): 1944-51, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23415087
13.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Commun Biol
; 6(1): 1074, 2023 10 21.
Artigo
Inglês
| MEDLINE | ID: mdl-37865687
14.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
J Med Chem
; 66(4): 2918-2945, 2023 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36727211
15.
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Commun Biol
; 5(1): 787, 2022 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35931745
16.
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
J Med Chem
; 65(9): 6940-6952, 2022 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35471939
17.
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.
J Bacteriol
; 193(16): 4214-23, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21665968
18.
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.
J Bacteriol
; 193(10): 2647-51, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21398531
19.
NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin α1ß1.
Proteins
; 79(8): 2530-42, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21656569
20.
Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain.
Apoptosis
; 16(5): 460-7, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21340509